Love is a poison, intoxicating the heart. Yet in the end, it’s Poisonous Love that makes the heart race. When the marriage of beautiful cardiologist Preminsee is ruined by Naphak, an actress known for her villainous roles, the doctor isn't sure whether to despise or thank her. But little does she know that the two women have already met before, and the villainess is now determined to make Preminsee hers, no matter the cost.