Someone is working their way through the multiverse, leaving a trail of dead spiders in their wake! As the Superior Spider-Man faces this foe in the future, MC2's Spider-Girl finds herself under attack! Spider-themed heroes everywhere, in every world, begin to falter and fall. How can our Spider-Man possibly hope to survive against this interdimensional onslaught.

Collecting: Amazing Spider-Man #7-15, Superior Spider-Man #32-33, Free Comic Book Day 2014 (Guardians of the Galaxy) 1 (5 page Spider-Man story), Spider-Verse #1-2, Spider-Verse Team-Up #1-3, Scarlet Spiders #1-3, Spider-Woman #1-4, Spider-Man 2099 #5-8.