Mary Evelyn Hitchcock also published under the name Mrs. R.D. Hitchcock.

In 1898, Hitchcock travelled on a steamer ship from San Francisco to Klondike with her friend Edith Van Buren. She later wrote about this journey in her book, "Two Women in the Klondike." She also gave a series of lectures for charity on the mining and agricultural possibilities of the Yukon.

Hitchcock returned to the north for almost five years, and staked more than 100 claims.